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First Complete Sequence of a Human Genome
National Institutes of Health
The Human Genome Project, completed in 2003, covered about 92% of the total human genome sequence. The technologies to decipher the gaps that remained didn’t exist at the time. But scientists knew that the last 8% likely contained information important for fundamental biological processes.
Since then, researchers have developed better laboratory tools, computational methods, and strategic approaches. The final, complete human genome sequence was described in a set of six papers in the April 1, 2022, issue of Science. Companion papers were also published in several other journals.
The work was done by the Telomere to Telomere (T2T) consortium. T2T is led by researchers at NIH’s National Human Genome Research Institute (NHGRI), the University of California, Santa Cruz, and the University of Washington, Seattle. NHGRI was the primary funder.
“Short-read” technologies were originally used to sequence the human genome. These provide several hundred bases of DNA sequence at a time, which are then stitched together by computers. Such methods still leave some gaps in genome sequences.
Over the past decade, two new DNA sequencing technologies emerged that can read longer sequences without compromising accuracy. The PacBio HiFi DNA sequencing method can read about 20,000 letters with nearly perfect accuracy. The Oxford Nanopore DNA sequencing method can read even more—up to 1 million DNA letters at a time—with modest accuracy. Both were used to generate the complete human genome sequence.
In total, the new project added nearly 200 million letters of the genetic code. This last 8% of the genome includes numerous genes as well as repetitive DNA sequences, which may influence how cells function. Most of the newly added sequences were in the centromeres, the dense middle sections of chromosomes, and near the repetitive ends of each chromosome.
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Participate in Research Studies
APTA Home Health receives frequent requests from members and students to disseminate their research study surveys to our members in hopes of increasing volunteer engagement. As we receive these requests, we will post them here in our bi-weekly e-newsletter. Please note that these research studies are not affiliated with or sponsored by APTA Home Health and are 100% volunteer based. Any questions or concerns should be directed to the contact listed for the study.
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Imposter Phenomenon Survey
Physical Therapists from West Coast University are seeking participation in a survey regarding the prevalence of Imposter phenomenon in licensed physical therapists. Imposter Phenomenon, or perceived fraudulence, describes an ongoing fear of exposure as a fraud despite objective successes and accomplishments.
The organizers of the study are hoping to gather data regarding not only the prevalence, but predictors and if there is a correlation to burnout within our profession.
The survey will only take about 15 minutes to complete. Please only take this survey once, as you may see it on multiple outlets. Your participation is greatly appreciated! Please contact [email protected] with any questions you may have.
Use the following link to access the survey and complete it by July 8, 2022:
Follow this link to the Survey:
https://docs.google.com/forms/d/1PgsmWEefs9EwnnQCTbSgL771D1wZAG-P4xSlxIP4kbw/viewform?ts=62811d86&edit_requested=true
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Assessment of Balance Practices and Associated Barriers of United States Practicing Physical Therapists
A doctoral student at Seton Hall University is conducting a mixed-method study (IRB number 2022-298 ). The study will explore the balance assessment practices of U.S.-practicing PTs, specifically, addressing the utilization of American Physical Therapy Association (APTA)balance tests and measures and the Academy of the Geriatric Physical Therapy (AGPT) Clinical Guidance Statement (CGS) in the management of falls. The survey has two parts and will take 15 minutes to complete. The survey is anonymous and confidential.
If you have any questions, please contact the primary investigator, Franceah Palencia-Quijano at [email protected].
Use the following link to access the survey and complete it by June 19, 2022:
Follow this link to the Survey:
https://shu.co1.qualtrics.com/jfe/form/SV_bPnCrt7mNqOBtI2
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Join Us for Tomorrow's Virtual Town Hall
When: Wednesday, July 13, 2022 | 8:30pm - 9:30pm ET
This virtual town hall is open to APTA Home Health members only.
Please join us to discuss upcoming House of Delegates elections and motions! This is also an open-forum for member comments, concerns and feedback!
Members, if you are able to attend, please register here for FREE: https://aptahhs.memberclicks.net/july22_townhall |
Home Health Toolbox II: Tests & Measures For Use in the Home
Published in February 2022, the Home Health Toolbox II, for use by physical therapy practitioners and researchers, is an impressive and comprehensive aggregation of assessments across multiple domains, ranging widely from physical capacity to cognitive functioning to social factors impacting health and functioning. A selection of these assessments can give a full picture of a patient’s status in the home setting and should play an important role in characterizing a patient’s problems and challenges, developing a treatment plan and following progress over time.
The value of this Toolbox is that its developers have carefully screened for instruments that will work in the home setting and describe their strengths, weaknesses, technical requirements and interpretation.
APTA Home Health Member Price:
- Digital: FREE
- Print Copy: $17.99
Non-Member Price:
- Digital Copy: $25.00
- Print Copy: $29.99
To purchase your copy, click here! |
ACHH Graduate Virtual Journal Club
When: Thursday, January 12, 2023 | 7:00pm - 8:30pm Eastern
Article For January 2023 Discussion: TUG-10: A Modification of the Timed Up and Go Test for Aerobic Assessment in Older Adults
The ACHH faculty have worked with the APTA Home Health Board to initiate a journal club exclusively for the PT and PTA graduates of the ACHH certification program.
The FREE ACHH journal club will take place three times a year on the second Thursday of January, May, and September, from 7:00pm – 8:30pm EST. The first 30 minutes will be a happy hour of networking and discussion and then one member will lead a guided journal club. Participation in the club will carry points towards recertification, with one point for each club attended, to a maximum of 5, and 3 points for the individual leading the discussion. The club will be held virtually, and details and the link will be sent by the section to all graduates of the program. It is planned that the topics will rotate through different major areas such as neurological, cardiopulmonary, musculoskeletal and issues specific to PTAs.
The next event will be on Thursday, January 12, 2023. Any volunteers to lead journal discussions in the subsequent meetings will be appreciated. Remember - 3 points will be awarded towards your ACHH Certification Renewal if you volunteer to lead these discussions. If interested, please email us at [email protected].
ACHH program graduates, click here to register for free! |
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